heme oxygenase-1 (HMOX1, heat shock protein 32, HO1)

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Function

                    heme oxygenase
                  cyt P450 reductase
heme[Fe+2] + O2   ------------------>   biliverdin + CO + Fe+2
+ NADPH + H+                            + NADP+  + H2O
                biliverdin reductase
   biliverdin    ------------------>   bilirubin + NADP+
 + NADPH + H+

Structure

belongs to the heme oxygenase family

Compartment

microsome

Expression

More general terms

Additional terms

References

  1. Snyder SH. Nitric oxide: first in a new class of neurotransmitters. Science. 1992 Jul 24;257(5069):494-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1353273
  2. Smith MA, Kutty RK, Richey PL, Yan SD, Stern D, Chader GJ, Wiggert B, Petersen RB, Perry G. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. Am J Pathol. 1994 Jul;145(1):42-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8030754 1994
  3. Sedlak TW, Snyder SH. Messenger molecules & cell death: therapeutic implications. JAMA. 2006 Jan 4;295(1):81-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16391220
  4. UniProt http://www.uniprot.org/uniprot/P09601.html

Database