transglutaminase-2 (tissue transglutaminase, tranglutaminase-C, TGM2)

Function

• catalyzes the cross-linking of proteins & the conjugation of polyamines to proteins
• gliadin is a preferred substrate

protein glutamine + alkylamine
               <-->
protein N(5)-alkylglutamine + NH3

Cofactor: binds 1 Ca+2 per subunit (putative)

Structure

• monomer
• belongs to the transglutaminase superfamily transglutaminase family

Alternative splicing

named isoforms=3

Expression

• ubiquitous
• induced by retinoic acid

Pathology

• defects in TGM2 are involved in early-onset diabetes type 2
• autoantigen of celiac disease

More general terms

• transglutaminase
• phosphoprotein

Additional terms

• anti-tissue transglutaminase IgA autoantibody
• celiac sprue (gluten-sensitive enteropathy)

Database

• UniProt: http://www.uniprot.org/uniprot/P21980.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7052
• OMIM: https://mirror.omim.org/entry/190196
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7052