anti-tissue transglutaminase IgA autoantibody

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Etiology

celiac disease is precipitated by ingestion of the protein gliadin, a component of wheat gluten
gliadin initiates mucosal damage which involves an immunological process in individuals with a genetic predisposition
IgA antibodies against gliadin & endomysium, a structure of smooth muscle connective tissue are found in patients with celiac disease
tissue transglutaminase is the endomysial autoantigen
gliadin is a preferred substrate for tissue transglutaminase

↑ Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997 Jul;3(7):797-801. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9212111
↑ Dieterich W, Laag E, Schopper H, Volta U, Ferguson A, Gillett H, Riecken EO, Schuppan D. Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology. 1998 Dec;115(6):1317-21 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9834256
↑ Sulkanen S, Halttunen T, Laurila K, Kolho KL, Korponay-Szabo IR, Sarnesto A, Savilahti E, Collin P, Maki M. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology. 1998 Dec;115(6):1322-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9834257
↑ Blackwell PJ, Hill PG, Holmes GK. Autoantibodies to human tissue transglutaminase: superior predictors of coeliac disease. Scand J Gastroenterol. 2002 Nov;37(11):1282-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12465726
↑ Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
↑ Tissue Transglutaminase (tTG) Ab, IgA Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0050734.jsp
↑ Tissue Transglutaminase (tTG) Ab, IgA Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0097709.jsp