tissue transglutaminase IgA in serum
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Indications
- evaluation of celiac disease
* titers >= 10X upper limit of normal diagnostic of celiac disease[9][10]
* rule out celiac disease prior to diagnosis of irritable bowel syndrome[8]
Clinical significance
- celiac disease is precipitated by ingestion of the protein gliadin, a component of wheat gluten
- gliadin initiates mucosal damage which involves an immunological process in individuals with a genetic predisposition
- IgA antibodies against gliadin & endomysium, a structure of smooth muscle connective tissue are found in patients with celiac disease
- tissue transglutaminase is the endomysial autoantigen
- gliadin is a preferred substrate for tissue transglutaminase
More general terms
Additional terms
References
- ↑ Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997 Jul;3(7):797-801. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9212111
- ↑ Dieterich W, Laag E, Schopper H, Volta U, Ferguson A, Gillett H, Riecken EO, Schuppan D. Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology. 1998 Dec;115(6):1317-21 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9834256
- ↑ Sulkanen S, Halttunen T, Laurila K, Kolho KL, Korponay-Szabo IR, Sarnesto A, Savilahti E, Collin P, Maki M. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology. 1998 Dec;115(6):1322-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9834257
- ↑ Blackwell PJ, Hill PG, Holmes GK. Autoantibodies to human tissue transglutaminase: superior predictors of coeliac disease. Scand J Gastroenterol. 2002 Nov;37(11):1282-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12465726
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
- ↑ Tissue Transglutaminase (tTG) Ab, IgA Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0050734.jsp
- ↑ Tissue Transglutaminase (tTG) Ab, IgA Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0097709.jsp
- ↑ 8.0 8.1 NEJM Knowledge+ Gastroenterology
- ↑ 9.0 9.1 Shiha MG et al. Accuracy of the no-biopsy approach for the diagnosis of celiac disease in adults: A systematic review and meta-analysis. Gastroenterology 2024 Apr; 166:620 PMID: https://www.ncbi.nlm.nih.gov/pubmed/38176661 Free article https://www.gastrojournal.org/article/S0016-5085(23)05688-3/fulltext
- ↑ 10.0 10.1 Penny HA et al. Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts. Gut 2021 May; 70:876. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33139268 PMCID: PMC8040155 Free PMC article https://gut.bmj.com/content/70/5/876