transgelin; smooth muscle protein 22-alpha; SM22-alpha; WS3-10; 22 kD actin-binding protein (TAGLN, SM22, WS3-10)

Function

• actin cross-linking/gelling protein (putative)
• involved in Ca+2 interactions & contractile properties of the cell that may contribute to replicative senescence

Structure

• belongs to the calponin family
• contains 1 calponin-like repeat
• contains 1 CH (calponin-homology) domain

Compartment

cytoplasm (probable)

Expression

overexpressed in senescent human fibroblasts

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q01995.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6876
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6876
• OMIM: https://mirror.omim.org/entry/600818