lactate dehydrogenase A or LDH M subunit

Function

• fermentation; pyruvate fermentation to lactate
• (S)-lactate from pyruvate: step 1/1

(S)-lactate + NAD+ <--> pyruvate + NADH

Structure

• homotetramer
• belongs to the LDH/MDH superfamily, LDH family

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Pathology

• defects in LDHA are a cause of exertional myoglobinuria

More general terms

• protein subunit
• phosphoprotein

Component of

• lactate dehydrogenase (LDH)

Database

• UniProt: http://www.uniprot.org/uniprot/P00338.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3939
• OMIM: https://mirror.omim.org/entry/150000
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3939