adrenomedullin (ADM, AM, PAMP)

From Aaushi

Jump to navigation Jump to search

^[1]^[2]^[3]

Function

potent hypotensive agent & vasodilatator
control of fluid & electrolyte homeostasis
in the kidney
- diuretic & natriuretic
- inhibits aldosterone secretion by direct adrenal actions
in pituitary gland
- inhibits basal ACTH secretion
  - appear to act in brain & pituitary gland to facilitate loss of plasma volume, contributing to hypotensive effect

Structure

belongs to the adrenomedullin family

Compartment

Expression

highest levels found in pheochromocytoma & adrenal medulla
also found in lung, ventricle & kidney tissues

Pathology

plasma ADM associated with loneliness^[3]

More general terms

secreted protein

References

↑ UniProt http://www.uniprot.org/uniprot/P35318.html
↑ NIEHS-SNPs http://egp.gs.washington.edu/data/adm/
↑ ^3.0 ^3.1 Shen C, Zhang R, Yu J, Sahakian BJ, Cheng W, Feng J. Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality. Nat Hum Behav. 2025 Jan 3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39753750

Database

Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=133
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:133
OMIM: https://mirror.omim.org/entry/103275
UniProt: http://www.uniprot.org/uniprot/P35318.html

Retrieved from "https://aaushi.info/w/index.php?title=A136745&oldid=1236928"

↑ Back to top