adrenomedullin (ADM, AM, PAMP)

Function

• potent hypotensive agent & vasodilatator
• control of fluid & electrolyte homeostasis
• in the kidney
  • diuretic & natriuretic
  • inhibits aldosterone secretion by direct adrenal actions
• in pituitary gland
  • inhibits basal ACTH secretion
    • appear to act in brain & pituitary gland to facilitate loss of plasma volume, contributing to hypotensive effect

Structure

belongs to the adrenomedullin family

Compartment

secreted

Expression

• highest levels found in pheochromocytoma & adrenal medulla
• also found in lung, ventricle & kidney tissues

More general terms

• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=133
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:133
• OMIM: https://mirror.omim.org/entry/103275
• UniProt: http://www.uniprot.org/uniprot/P35318.html