enolase-1; alpha enolase; phosphopyruvate hydratase; C-myc promoter-binding protein; plasminogen-binding protein (ENO1, ENO1L1, MBPB1, MPB1)

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Introduction

Formerly phosphopyruvate hydratase

Function

2-phospho-D-glycerate <--> phosphoenolpyruvate + H2O

Cofactor:

  • Mg+2, required for catalysis & for stabilizing the dimer

Structure

Compartment

Alternative initiation

Expression

  • alpha/alpha homodimer is expressed in embryo & in most adult tissues
  • alpha/beta heterodimer & beta/beta homodimer are found in striated muscle
  • the alpha/gamma heterodimer & the gamma/gamma homodimer are found in neurons
  • during ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, & to the alpha/gamma heterodimer in nerve cells

Pathology

Genetics

More general terms

References

Database