biology of aging

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Introduction

Also see age-related physiological changes.

Notes

Theories of aging

* telomere shortening does not play a causal role in aging[13]

no evolutionary theory of aging is universally accepted

aging did not evolve, longevity evolved

Models to test theories of aging

Technologies to test theories on aging

Transcriptional changes with aging

Genes implicated in aging process:

Cancer & Aging

  • cancer survivors are subject to an increased rate of aging with associated increase in all-cause & cancer-specific mortality[17]

More general terms

Additional terms

References

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  3. Mobbs, C, Molecular and biologic factors in aging. In: Geriatric Medicine: An Evidence-Based Approach, 4th ed, Cassel CK et al (eds), Springer-Verlag, New York, 2003 Johnson TE Increased life span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science 1990; 249:908
    Morris JZ et al, A phosphatidyl inositol 3-OH kinase family member regulating longevity and dipause in Caenorhabditis elegans. Nature 1996; 382:536
    Kimura KD et al, daf-2, an insulin receptor-like gene that regulates longevity and diapause Caenorhabditis elegans. Science 1997 277:942
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    Coschigano KT et al, Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 2000; 141:2608
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  6. Pinkston JM et al, Mutations that increase the life span of C. elegans inhibit tumor growth. Science 2006, 313:971 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16917064
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  8. 8.0 8.1 Miller T Proceedings of the 38th Annual Meeting of the American Aging Association: Integrative Biology: Hormones, Signaling, and Aging. May 29-June 1, 2009, Scottsdale, AZ
    Harrison DE et al Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009 Jul 8 http://dx.doi.org/10.1038/nature08221
  9. 9.0 9.1 9.2 9.3 9.4 9.5 Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
    Geriatric Review Syllabus, 9th edition (GRS9) Medinal-Walpole A, Pacala JT, Porter JF (eds) American Geriatrics Society, 2016
    Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022
  10. 10.0 10.1 Brewer GJ. Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories. Exp Gerontol. 2010 Mar;45(3):173-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19945522
  11. Ljubuncic P, Reznick AZ. The evolutionary theories of aging revisited--a mini-review. Gerontology. 2009;55(2):205-16 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19202326
  12. Ludlow AT, Roth SM. Physical activity and telomere biology: exploring the link with aging-related disease prevention. J Aging Res. 2011 Feb 21;2011:790378. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21403893
  13. 13.0 13.1 Simons MJ Questioning causal involvement of telomeres in aging. Ageing Res Rev. 2015 Aug 21 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26304838
  14. Vijg J. Aging genomes: a necessary evil in the logic of life. Bioessays. 2014 Mar;36(3):282-92. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24464418
  15. 15.0 15.1 Davidsohn N, Pezzone M, Vernet A et al A single combination gene therapy treats multiple age-related diseases. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23505-23511. PMID: https://www.ncbi.nlm.nih.gov/pubmed/31685628 Free PMC Article
  16. Wikipedia: Disposable soma theory of aging https://en.wikipedia.org/wiki/Disposable_soma_theory_of_aging
  17. 17.0 17.1 Zhang D, Leeuwenburgh C, Zhou D et al Analysis of Biological Aging and Risks of All-Cause and Cardiovascular Disease- Specific Death in Cancer Survivors. JAMA Netw Open. 2022;5(6):e2218183. June 22 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35731518 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2793435
  18. 18.0 18.1 18.2 Oh HS et al. Organ aging signatures in the plasma proteome track health and disease. Nature 2023 Dec 6; 624:164. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38057571 PMCID: PMC10700136 Free PMC article. https://www.nature.com/articles/s41586-023-06802-1