free radical

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^[1]^[2]

Introduction

A reactive molecule (radical) of short 1/2life implicated in:

aging^[1]
degenerative diseases^[2]
- cancer
- atherosclerosis
- neurodegenerative diseases
oxidative stress Free implicates diffusion with reaction at a site distant to the site of generation (distinguished radicals within a solvent of compartmental cage).

More general terms

radical

References

↑ ^1.0 ^1.1 Harman D, Aging: a theory based on free radical and radiation chemistry, J Gerontol 11:298, 1956
↑ ^2.0 ^2.1 Harman D, Free radical theory of aging: Role of free radicals in the origination and evolution of life, aging and disease processes. In: Johnson JE et al (eds), Free Radicals, Aging and Degenerative Diseases, New York, Liss, 1986

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