protein BHLHB9 (bHLHB9, transcription regulator of 60 kD, p60TRP, BHLHB9, KIAA1701)

Function

• may play a role in the control of cellular aging & survival

Structure

• belongs to the GPRASP family
• despite its name, no basic helix-loop-helix (bHLH) domain is detected by any prediction tool

Compartment

• cytoplasm, nucleus
• mainly cytoplasmic, & nuclear at lower level

Expression

• highly expressed in brain
• not expressed in lung or liver

Pathology

• down-regulated in brain from patients suffering from Alzheimer disease
• down-regulated in colon cancer cells, due to CpG hypermethylation of its promoter

More general terms

• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8082
• UniProt: http://www.uniprot.org/uniprot/Q6PI77.html