silent information regulator 2 (Sir2) protein

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[1][2]

Introduction

NAD-dependent yeast histone deacetylase. mouse homolog sir2-alpha, human homolog SIRT1. Reduces chromatin fragmentation, a component of yeast senescence. Effects on senescence may be mediated through NAD-dependent effects on glucose metabolism

More general terms

References

  1. ↑ Luo et al. Cell 107:137-148, 2001
  2. ↑ Mobbs, C, Molecular and biologic factors in aging. In: Geriatric Medicine: An Evidence-Based Approach, 4th ed, Cassel CK et al (eds), Springer-Verlag, New York, 2003
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