homeostenosis
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Introduction
As an individual ages, the amount of physiological reserves available to counter any challenge to homeostasis decreases. Eventually, physiologic reserves are needed to maintain homeostasis in the absence of a challenge.
Notes
- ref[2] cites an alleged example homeostensosis:
- a mouse model of shortened life span with multiple progressive age-related phenotypes
- they treated with a drug to target & remove p16ink4a- expressing cells
- this delayed onset of skeletal muscle loss, cataracts & adiposity
- they did not live longer, but appeared healthier for a longer period of time