homeostenosis

Introduction

As an individual ages, the amount of physiological reserves available to counter any challenge to homeostasis decreases. Eventually, physiologic reserves are needed to maintain homeostasis in the absence of a challenge.

Notes

• ref cites an alleged example homeostensosis:
  • a mouse model of shortened life span with multiple progressive age-related phenotypes
  • they treated with a drug to target & remove p16ink4a- expressing cells
  • this delayed onset of skeletal muscle loss, cataracts & adiposity
  • they did not live longer, but appeared healthier for a longer period of time