disks large-associated protein 2; DAP-2; SAP90/PSD-95-associated protein 2; SAPAP2; PSD-95/SAP90-binding protein 2 (DLGAP2, DAP2)

Function

• may play a role in the molecular organization of synapses & neuronal cell signaling
• could be an adapter protein linking ion channel to the subsynaptic cytoskeleton
• may induce enrichment of PSD-95/SAP90 at the plasma membrane
• interacts with DLG1 & DLG4/PSD-95 (putative)

Structure

belongs to the SAPAP family

Compartment

• cell membrane; peripheral membrane protein (putative)
• cell junction, synapse, postsynaptic cell membrane, postsynaptic density (putative)
• postsynaptic density of neuronal cells (putative)

Alternative splicing

named isoforms=3

Expression

expressed in brain & kidney

More general terms

• phosphoprotein

Additional terms

• disks large homolog 4; postsynaptic density protein 95; PSD-95; synapse-associated protein 90; SAP90 (DLG4, PSD95)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9228
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9228
• OMIM: https://mirror.omim.org/entry/605438
• UniProt: http://www.uniprot.org/uniprot/Q9P1A6.html