heat shock factor-binding protein 1; heat shock factor-1 binding protein; nasopharyngeal carcinoma-associated antigen 13; NPC-A-13 (HSBP1, HSF1BP)

Function

• negative regulator of the heat shock response
• negatively affects HSF1 DNA-binding activity
• may have a role in suppressing activation of the stress response during the aging process
• associates with heptad repeats of HSF1 trimers & probably also HSF1 monomers, & with HSP70
• association with HSF1 trimers & HSP70 coincides with attenuation of heat shock response & the conversion of HSF1 trimer to monomer

Structure

belongs to the HSBP1 family

Compartment

nucleus

More general terms

• heat shock protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3281
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3281
• OMIM: https://mirror.omim.org/entry/604553
• UniProt: http://www.uniprot.org/uniprot/O75506.html