klotho peptide

^[1]^[2]^[3]

Function

CSF Klotho levels are diminished in patients with Alzheimer's dementia relative to normal controls & persons with mild cognitive impairment^[2]
diminished CSF Klotho levels are are associated with increased CSF beta-amyloid & CSF p-tau^[2]

a single injection of low-dose klotho enhances memory in aged nonhuman primates
- high-dose klotho does not enhance memory^[3]

↑ UniProt http://www.uniprot.org/uniprot/Q9UEF7.html
↑ ^2.0 ^2.1 ^2.2 Grontvedt GR, Sando SB, Lauridsen C et al Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden. JAMA Netw Open. 2022;5(11):e2243232.
↑ ^3.0 ^3.1 Tozer L. Anti-ageing protein injection boosts monkeys's memories. First primate studies to show cognitive benefits of the protein klotho could be a step towards clinical applications. Nature News. 2023. July 4. https://www.nature.com/articles/d41586-023-02214-3
Castner SA, Gupta S, Wag D et al Longevity factor klotho enhances cognition in aged nonhuman primates. Nature Aging. 2023, July 3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37400721 https://www.nature.com/articles/s43587-023-00441-x