high fat diet
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Epidemiology
- high fat diet associated with lower mortality than high carbohydrate diet[2]
Comparative biology
- in mice, a high-fat diet induces PPAR-delta in intestinal stem cells & (non-stem cell) progenitor cells[1]
- enforced PPAR-delta signalling permits these progenitors to form in vivo tumurs after loss of the tumor suppressor APC[1]
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References
- ↑ 1.0 1.1 1.2 Beyaz S, Mana MD, Roper J et al High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature 531:5358. March 3 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26935695 <Internet> http://www.nature.com/nature/journal/v531/n7592/full/nature17173.html
- ↑ 2.0 2.1 Dehghan M, Mente A, Zhang X et al Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study. Lancet. Aug 29, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28864332 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32252-3/fulltext
Ramsden CE, Domenichiello AF PURE study challenges the definition of a healthy diet: but key questions remain. Lancet. Aug 29, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28864330 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32241-9/fulltext