age-related physiological changes
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Introduction
General
- diminished ability to maintain homeostasis
- stress-induced changes more marked than changes at rest
- variability increases among individuals
- body size & composition
- decreased lean/fat body ratio
- decreased height after age 30-40
- increased weight up to age 50 in men, 60 in women, then a decline
- total body water decreases
- diminished bone mass & total body Ca+2
- motor skills
- pharmacokinetics
- increased 1/2life of lipid-soluble drugs
- increased peak concentration of hydrophilic drugs
- increased time for drug clearance
More specific terms
- age-associated changes in adipose tissue
- age-associated changes in cardiovascular function
- age-associated changes in hearing
- age-associated changes in hematologic function
- age-associated changes in hematopoiesis
- age-associated changes in immunity; immunosenescence
- age-associated changes in metabolism
- age-associated changes in pulmonary function
- age-associated changes in renal function
- age-associated changes in skeletal muscle
- age-associated changes in sleep
- age-associated changes in smell
- age-associated changes in teeth
- age-associated changes in temperature regulation
- age-associated changes in the autonomic nervous system
- age-associated changes in the central nervous system
- age-associated changes in the digestive system
- age-associated changes in the endocrine system
- age-associated changes in the eye
- age-associated changes in the peripheral nervous system
- age-associated changes in the reproductive system
- age-associated changes in the skeletal system
- age-associated changes in the urinary system
- age-associated changes in the vestibular system
- age-associated changes in thirst
- neuropsychiatric features of aging
- pharmacokinetics in the elderly
- skin aging (includes aging of skin appendages)
Additional terms
- age-related endocrinopathy
- aging
- biology of aging
- confounding factors in evaluation of age related changes
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ Mader S: in: Intensive Course in Geriatric Medicine & Board Review, Santa Monica, CA, Sept 20-23, 2000
- ↑ Essentials of Clinical Geriatrics, 4th ed, Kane RL et al (eds) McGraw Hill, NY, 1999
- ↑ UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
- ↑ McPherson, S. Director, Neuropsychology Laboratory UCLA ADRC
- ↑ Journal Watch 22(2):17, 2002
- ↑ Mader S: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 25-28, 2002
- ↑ Geriatrics Review Syllabus, American Geriatrics Society, 5th edition, 2002-2004
Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013 - ↑ Taffet GE, Physiology of Aging, In: Geriatric Medicine: An Evidence-Based Approach, 4th ed, Cassel CK et al (eds), Springer-Verlag, New York, 2003
- ↑ Mader S: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 29-Oct 2, 2004
- ↑ Alessi C: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 29-Oct 2, 2004
- ↑ The Merck Manual of Geriatrics, 3rdh ed, Merck & Co, Rahway NJ, 2000
- ↑ Manor B, Costa MD, Hu K et al Physiological complexity and system adaptability: evidence from postural control dynamics of older adults. J Appl Physiol (1985). 2010 Dec;109(6):1786-91. Epub 2010 Oct 14. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20947715