age-associated changes in immunity; immunosenescence

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Introduction

Changes in immunity with age include changes in cellular immunity, humoral immunity & innate immunity.

Pathology

Changes in T-cells with aging

Changes in B-cells with aging

Changes in cytokines with aging

Changes in interleukins with aging

Physiology

More general terms

Additional terms

References

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  2. UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 29-Oct 2, 2004
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  5. Burns EA & Goodwin JS, Immunology of Aging In: Geriatric Medicine: An Evidence-Based Approach, 4th ed, Cassel CK et al (eds), Springer-Verlag, New York, 2003
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010
    Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
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  8. 8.0 8.1 Buck Institute for Research on Aging 'Clock' created to predict immunological health and chronic diseases of aging Research highlights the critical role of the immune system in the aging process. Science Daily. Science News. July 12, 2021 https://www.sciencedaily.com/releases/2021/07/210712122159.htm
    Sayed N, Huang Y, Nguyen K et al An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging. Nature Aging 2021 Not indexed in PubMed https://www.nature.com/articles/s43587-021-00082-y
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  10. Margolick JB, Leng SX Johns Hopkins. Geriatric Medicine & Gerontology Immune Senescence https://www.hopkinsmedicine.org/geriatric_medicine_gerontology/aging_research/biology_healthy_aging/immune_senescence.html
  11. Frasca D, Diaz A, Romero M etl al B Cell Immunosenescence. Annu Rev Cell Dev Biol. 2020 Oct 6;36:551-574 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33021823 Free PMC article. https://www.annualreviews.org/doi/abs/10.1146/annurev-cellbio-011620-034148
  12. Thio HB Aging immune system (immunosenescence) and the skin Webinar on Cosmetology and Trichology, September 04, 2020 J Ageing & Geriatr Med. 2020. Sept 4. https://www.scitechnol.com/peer-review/aging-immune-system-immunosenescence-and-the-skin-GRAf.pdf
  13. Crooke SN, Ovsyannikova IG, Poland GA, Kennedy RB Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses. Exp Gerontol. 2019 Sep;124:110632 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31201918 PMCID: PMC6849399 Free PMC article