C-X-C motif chemokine 9; gamma-interferon-induced monokine; monokine induced by interferon-gamma; HuMIG; MIG; small-inducible cytokine B9 (CXCL9, CMK, MIG, SCYB9)
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Function
- cytokine
- affects growth, movement, or activation state of cells that participate in immune & inflammatory response
- chemotactic for activated T-cells
- upregulates multiple genes implicated in inflammation
- binds to CXCR3
Structure
- belongs to the intercrine alpha (chemokine CxC) family
Compartment
Expression
- induced by IFNG/IFN-gamma
- induction is enhanced by TNF in dermal fibroblasts & vein endothelial cells
Pathology
- role in cellular senescence, vascular aging & adverse cardiac remodeling[3]
- silencing CXCL9 reverses age-related endothelial dysfunction in humans
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q07325.html
- ↑ Wikipedia; Note: CXCL9 entry http://en.wikipedia.org/wiki/CXCL9
- ↑ 3.0 3.1 Buck Institute for Research on Aging 'Clock' created to predict immunological health and chronic diseases of aging Research highlights the critical role of the immune system in the aging process. Science Daily. Science News. July 12, 2021 https://www.sciencedaily.com/releases/2021/07/210712122159.htm
Sayed N, Huang Y, Nguyen K et al An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging. Nature Aging 2021 Not indexed in PubMed https://www.nature.com/articles/s43587-021-00082-y