C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; interferon-inducible protein 10 receptor; IP-10 receptor; CKR-L2; G protein-coupled receptor 9; CD183 (CXCR3, GPR9)

Function

• receptor for CXCL9, CXCL10 & CXCL11
• mediates proliferation of human mesangial cells (HMC)
• isoform 2 is a receptor for CXCL4 & also mediates inhibitory activities of CXCL9, CXCL10 & CXCL11 on growth of human microvascular endothelial cells
• isoform 2 may play a role in angiogenesis
• isoform 3 mediates activity of CXCL11

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Alternative splicing

named isoforms=3; exon skipping

Expression

• isoform 1 & isoform 2 are mainly expressed in heart, kidney, liver & skeletal muscle
• isoform 1 is also expressed in placenta

More general terms

• CXC chemokine receptor
• G-protein coupled receptor; serpentine receptor
• CD antigen
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2833
• OMIM: https://mirror.omim.org/entry/300574
• UniProt: http://www.uniprot.org/uniprot/P49682.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2833