C-X-C motif chemokine 11; beta-R1; H174; interferon gamma-inducible protein 9; IP-9; interferon-inducible T-cell alpha chemoattractant; I-TAC; small-inducible cytokine B11 (CXCL11, ITAC, SCYB11, SCYB9B)

Function

• chemotactic for interleukin-activated T-cells
• not chemotactic for unstimulated T-cells, neutrophils or monocytes
• induces Ca+2 release in activated T-cells
• binds to CXCR3
• may play a role in CNS diseases which involve T-cell recruitment
• may play a role in skin immune responses

Structure

• belongs to the intercrine alpha (chemokine CxC) family

Compartment

secreted

Expression

• high levels in peripheral blood leukocytes, pancreas & liver astrocytes
• moderate levels in thymus, spleen & lung
• low levels in placenta, prostate & small intestine
• also found in epidermal basal layer keratinocytes in skin disorders
• induced by IFN-gamma & IFNB1/IFN-beta
• induction by IFN-gamma is enhanced by
  • TNF in monocytes, dermal fibroblasts & endothelial cells
  • IL-1 in astrocytes

More general terms

• CXC chemokine; alpha chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6373
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6373
• OMIM: https://mirror.omim.org/entry/604852
• UniProt: http://www.uniprot.org/uniprot/O14625.html