C-X-C motif chemokine 10; 10 kD interferon gamma-induced protein; gamma-IP10; IP-10; small-inducible cytokine B10; contains: CXCL10(1-73) (CXCL10, INP10, SCYB10)
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Function
- chemotactic for monocytes & T-lymphocytes
- binds to CXCR3
- CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes
- may be a mediator of the IFN-gamma response
Structure
- belongs to the intercrine alpha (chemokine CxC) family
Compartment
Expression
- induced by IFN-gamma
- a diverse population of cell types rapidly increases transcription of mRNA encoding this protein
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P02778.html
- ↑ Wikipedia; Note: CXCL10 entry http://en.wikipedia.org/wiki/CXCL10