age-associated changes in hematologic function
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Introduction
The hematologic system undergoes change with aging.
Physiology
- age-associated changes in hematopoiesis
- increased tendency for hypercoagulability
- enhanced formation of fibrin & secondary fibrinolysis
- increased plasma fibrinogen & plasma factor VIII
- other coagulation factors are not elevated
- centenarians have
- increased frequency of genetic markers for risk of hypercoagulabiltiy
- 4G allele of the PAI-1-675 (4G/5G) polymorphism
- mutant factor V (Arg506Gln)
- prothrombin gene G20210A mutation
- increased plasma Von Willebrand factor (VWF)
- high prevalence of anti-phospholipids antibodies
- high plasma levels of the coagulation activation markers in older persons not necessarily associated with high risk of arterial thrombosis or venous thrombosis[2]
- increased frequency of genetic markers for risk of hypercoagulabiltiy
More general terms
More specific terms
References
- ↑ Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
- ↑ 2.0 2.1 Mari D, Coppola R, Provenzano R. Hemostasis factors and aging. Exp Gerontol. 2008 Feb;43(2):66-73 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17869046