centenarian
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Introduction
Individials >= 100 years of age
Epidemiology
- 1 per 5000 in developed countries[1]
- female centenarians outnumber males 9 to 1
- men are more likely to be functionally independent than women
- male centenarians less likely to have chronic diseases than females
- male centenarians more likely to take fewer medications than females[1]
Pathology
- processes that improve lifespan also improve healthspan
- diseases occur later in life compressing time associated with morbidity
Genetics
- proteins increased in centenarians
Clinical manifestations
- centenarians maintain cognitive function in most domains for up to 4 years[2] with slight risk of memory loss
- BMI < 27 among 8 WW II veteran centenarians[3]
Management
- a healthy lifestyle increases the likelihood of becoming a centenarian[4]
Additional terms
References
- ↑ 1.0 1.1 1.2 Geriatric Review Syllabus, 10th edition (GRS10) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2019
- ↑ 2.0 2.1 George J High Cognitive Performance at Age 100 - Some centenarians show resilience to cognitive decline, despite brain pathology. MedPage Today January 15, 2021 https://www.medpagetoday.com/neurology/dementia/90720
Beker N, Ganz A, Hulsman M et al Association of Cognitive Function Trajectories in Centenarians With Postmortem Neuropathology, Physical Health, and Other Risk Factors for Cognitive Decline. JAMA Netw Open. 2021;4(1):e2031654. Jan 15 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33449094 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2775218 - ↑ 3.0 3.1 3.2 Kheirbek RE et al Life at the Extreme: Characteristics of Veteran Centenarians in Long-term Care. Annals of Long-Term Care. Oct. 2018 https://www.hmpgloballearningnetwork.com/site/altc/articles/life-extreme-characteristics-veteran-centenarians-long-term-care
- ↑ 4.0 4.1 Li Y, Wang L, Jigeer G et al Healthy Lifestyle and the Likelihood of Becoming a Centenarian. JAMA Netw Open. 2024;7(6):e2417931. June 20 PMID: https://www.ncbi.nlm.nih.gov/pubmed/38900423 Free article. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820220