centenarian

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Introduction

Individials >= 100 years of age

Epidemiology

  • 1 per 5000 in developed countries[1]
  • female centenarians outnumber males 9 to 1
  • men are more likely to be functionally independent than women
  • male centenarians less likely to have chronic diseases than females
  • male centenarians more likely to take fewer medications than females[1]

Pathology

Genetics

(biochemistry)

  • proteins increased in centenarians

Clinical manifestations

Management

Additional terms

References

  1. 1.0 1.1 1.2 Geriatric Review Syllabus, 10th edition (GRS10) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2019
  2. 2.0 2.1 George J High Cognitive Performance at Age 100 - Some centenarians show resilience to cognitive decline, despite brain pathology. MedPage Today January 15, 2021 https://www.medpagetoday.com/neurology/dementia/90720
    Beker N, Ganz A, Hulsman M et al Association of Cognitive Function Trajectories in Centenarians With Postmortem Neuropathology, Physical Health, and Other Risk Factors for Cognitive Decline. JAMA Netw Open. 2021;4(1):e2031654. Jan 15 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33449094 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2775218
  3. 3.0 3.1 3.2 Kheirbek RE et al Life at the Extreme: Characteristics of Veteran Centenarians in Long-term Care. Annals of Long-Term Care. Oct. 2018 https://www.hmpgloballearningnetwork.com/site/altc/articles/life-extreme-characteristics-veteran-centenarians-long-term-care
  4. 4.0 4.1 Li Y, Wang L, Jigeer G et al Healthy Lifestyle and the Likelihood of Becoming a Centenarian. JAMA Netw Open. 2024;7(6):e2417931. June 20 PMID: https://www.ncbi.nlm.nih.gov/pubmed/38900423 Free article. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820220