age-associated changes in pulmonary function

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Introduction

Pulmonary function declines with age

Pharmacology

Physiology

* GRS11[5] notes a loss of elastin fibers & an increase in cross-linking (unspecified), then goes on to mention a remodeling of the lung elastin-collagen network contributing to chest wall stiffness & decreases in peak expiratory flow in the elderly

* GRS11[5] seems to infer that loss of elastin fiber cross-links is not associated with age-associated decline in exercise tolerance

More general terms

Additional terms

References

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  2. UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 29-Oct 2, 2004
  3. The Merck Manual of Geriatrics, 3rdh ed, Merck & Co, Rahway NJ, 2000
  4. Taffet GE, Physiology of Aging, In: Geriatric Medicine: An Evidence-Based Approach, 4th ed, Cassel CK et al (eds), Springer-Verlag, New York, 2003
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
    Geriatric Review Syllabus, 10th edition (GRS10) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2019
    Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022
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  8. Roman MA, Rossiter HB, Casaburi R. Exercise, ageing and the lung. Eur Respir J. 2016;48(5):1471-1486 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27799391 Free article https://erj.ersjournals.com/content/48/5/1471
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  10. 10.0 10.1 10.2 Schumm B et al. Lung aerosol particle emission increases with age at rest and during exercise. Proc Natl Acad Sci U S A 2023 May 22; 120:e2301145120 https://www.pnas.org/doi/10.1073/pnas.2301145120
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