inactive neutral ceramidase B; inactive N-acylsphingosine amidohydrolase 2B; inactive non-lysosomal ceramidase B; ASAH2-like protein (ASAH2B, ASAH2L)

Structure

• belongs to the neutral ceramidase family
• in contrast to other members of the family, ASAH2B has no predicted transmembrane domain, & lacks the active site, suggesting that it may be inactive

Expression

ubiquitous

Pathology

• ASAH2B/ASAH2L shows diminished expression with increasing age, diminished expression in females across ages, & further decline in late-onset Alzheimer disease patients
• decline is even more pronounced in patients with an affected mother

Notes

• ASAH2B/ASAH2L is a partial paralog of ASAH2, resulting from a partial duplication of ASAH2 on chromosome 10
• it has a polymorphic start codon with a single nucleotide change of the original ASAH2 sequence plus other putative translation start site that might lead to several potential ORFs

More general terms

• ceramidase

Database

• UniProt: http://www.uniprot.org/uniprot/P0C7U1.html