histone deacetylase 7A (HDAC7A)

Function

• see histone deacetylase
• deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4)
• role in muscle maturation by repressing transcription of myocyte enhancer factors, including MEF2A, MEF2B & MEF2C
• during muscle differentiation, shuttles into the cytoplasm, allowing expression of myocyte enhancer factors (putative)
• may be involved in Epstein-Barr virus (EBV) latency, possibly by repressing viral BZLF1 gene
• interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 & MBD3
• interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B & MEF2C (putative)
• interacts with HTATIP & EDNRA
• interacts with JARID1B
• may be phosphorylated by CaMK1 (putative)
• activity is inhibited by trichostatin A (TSA), a known histone deacetylase inhibitor (putative)

Structure

• nuclear export sequence mediates the shuttling between nucleus & cytoplasm (putative)
• belongs to the histone deacetylase family, type 2 subfamily

Compartment

• nucleus, cytoplasm
• in the nucleus, associates with distinct subnuclear dot-like structures
• shuttles between nucleus & cytoplasm
• treatment with EDN1 results in shuttling from nucleus to the perinuclear region
• export to cytoplasm depends on the interaction with 14-3-3 protein YWHAE & may be due to its phosphorylation

Alternative splicing

named isoforms=4

More general terms

• histone deacetylase

Database

• OMIM: https://mirror.omim.org/entry/606542
• UniProt: http://www.uniprot.org/uniprot/Q8WUI4.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51564