MADS box transcription enhancer factor 2B; myocyte enhancer factor 2B (MEF2B)

Function

• transcription factor
• binds specifically to the MEF2 element present in regulatory regions of many muscle-specific genes
• activates transcription via MEF2 element
• involved in muscle-specific &/or growth factor-related transcription.
• interacts with HDAC7

Structure

heterodimer

Compartment

nucleus

Expression

• expressed in skeletal muscle, cardiac muscle, brain

More general terms

• MADS box transcription enhancer factor 2

Database

• OMIM: https://mirror.omim.org/entry/600661
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4207
• UniProt: http://www.uniprot.org/uniprot/Q02080.html