2016 WHO classification of mature lymphoid, histiocytic, & dendritic neoplasms
Jump to navigation
Jump to search
Classification
Mature B-cell neoplasms
- chronic lymphocytic leukemia/small lymphocytic lymphoma
- monoclonal B-cell lymphocytosis
- B-cell prolymphocytic leukemia
- splenic marginal zone lymphoma
- hairy cell leukemia
- splenic B-cell lymphoma/leukemia, unclassifiable (provisional)
- splenic diffuse red pulp small B-cell lymphoma (provisional)
- hairy cell leukemia-variant (provisional)
- lymphoplasmacytic lymphoma
- monoclonal gammopathy of undetermined significance (MGUS), IgM
- mu heavy chain disease
- gamma heavy chain disease
- alpha heavy chain disease
- monoclonal gammopathy of undetermined significance (MGUS), IgG/A
- plasma cell myeloma
- solitary plasmacytoma of bone
- extraosseous plasmacytoma
- monoclonal immunoglobulin deposition diseases
- extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
- nodal marginal zone lymphoma
- pediatric nodal marginal zone lymphoma (provisional)
- follicular lymphoma
- pediatric-type follicular lymphoma
- large B-cell lymphoma with IRF4 rearrangement (provisional)
- primary cutaneous follicle center lymphoma
- mantle cell lymphoma
- diffuse large B-cell lymphoma (DLBCL), NOS
- germinal center B-cell type
- activated B-cell type
- T-cell/histiocyte-rich large B-cell lymphoma
- primary DLBCL of the central nervous system (CNS)
- primary cutaneous DLBCL, leg type
- EBV positive DLBCL, NOS
- EBV positive mucocutaneous ulcer (provisional)
- DLBCL associated with chronic inflammation
- lymphomatoid granulomatosis
- primary mediastinal (thymic) large B-cell lymphoma
- intravascular large B-cell lymphoma
- ALK positive large B-cell lymphoma
- plasmablastic lymphoma
- primary effusion lymphoma
- HHV8 positive DLBCL, NOS (provisional)
- Burkitt lymphoma
- Burkitt-like lymphoma with 11q aberration (provisional)
- High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements
- High-grade B-cell lymphoma, NOS
- B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma
Mature T & NK neoplasms
- T-cell prolymphocytic leukemia
- T-cell large granular lymphocytic leukemia
- chronic lymphoproliferative disorder of NK cells (provisional)
- aggressive NK-cell leukemia
- systemic EBV positive T-cell lymphoma of childhood
- hydroa vacciniforme-like lymphoproliferative disorder
- adult T-cell leukemia/lymphoma
- extranodal NK-/T-cell lymphoma, nasal type
- enteropathy-associated T-cell lymphoma
- monomorphic epitheliotropic intestinal T-cell lymphoma
- indolent T-cell lymphoproliferative disorder of the GI tract (provisional)
- hepatosplenic T-cell lymphoma
- subcutaneous panniculitis-like T-cell lymphoma
- mycosis fungoides
- Sezarey syndrome
- primary cutaneous CD30 positive T-cell lymphoproliferative disorders
- lymphomatoid papulosis
- primary cutaneous anaplastic large cell lymphoma
- primary cutaneous gamma-delta T-cell lymphoma
- primary cutaneous CD8 positive aggressive epidermotropic cytotoxic T-cell lymphoma (provisional)
- primary cutaneous acral CD8 positive T-cell lymphoma (provisional)
- primary cutaneous CD4 positive small/medium T-cell lymphoproliferative disorder (provisional)
- peripheral T-cell lymphoma, NOS
- angioimmunoblastic T-cell lymphoma
- follicular T-cell lymphoma (provisional)
- nodal peripheral T-cell lymphoma with TFH phenotype (provisional)
- anaplastic large-cell lymphoma, ALK positive
- anaplastic large-cell lymphoma, ALK negative
- breast implant-associated anaplastic large-cell lymphoma (provisional)
Hodgkin lymphoma
- nodular lymphocyte predominant Hodgkin lymphoma
- classical Hodgkin lymphoma
- nodular sclerosis classical Hodgkin lymphoma
- lymphocyte-rich classical Hodgkin lymphoma
- mixed cellularity classical Hodgkin lymphoma
- lymphocyte-depleted classical Hodgkin lymphoma
Posttransplant lymphoproliferative disorders (PTLD)
- plasmacytic hyperplasia PTLD
- infectious mononucleosis PTLD
- florid follicular hyperplasia PTLD
- polymorphic PTLD
- monomorphic PTLD (B- and T-/NK-cell types)
- classical Hodgkin lymphoma PTLD
Histiocytic & dendritic cell neoplasms
- histiocytic sarcoma
- Langerhans cell histiocytosis
- Langerhans cell sarcoma
- indeterminate dendritic cell tumor
- interdigitating dendritic cell sarcoma
- follicular dendritic cell sarcoma
- fibroblastic reticular cell tumor
- disseminated juvenile xanthogranuloma
- Erdheim-Chester disease
References
- ↑ The 2016 revision of the World Health Organization classification of lymphoid neoplasms, Swerdlow SH et al. Blood 2016 https://ashpublications.org/blood/article/127/20/2375/35286/The-2016-revision-of-the-World-Health-Organization