heavy chain disease; Franklin disease

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Introduction

Lymphocytes secrete a defective heavy chain with an intact Fc fragment & a deletion in the Fd region. Alpha, gamma & mu heavy chain disease has been described. Epsilon & delta heavy chain disease has not been reported.

More general terms

More specific terms

References

  1. Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 744
  2. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 1624-255

Patient information

heavy chain disease patient information