interferon regulatory factor 4; lymphocyte-specific interferon regulatory factor; LSIRF; NF-EM5; multiple myeloma oncogene 1 (IRF4, MUM1)

Function

• transcriptional activator
• binds to the interferon-stimulated response element (ISRE) of the MHC class 1 promoter
• binds the immunoglobulin lambda light chain enhancer, together with PU.1
• probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells
• interacts with SPIB & DEF6
• role in hair color
  • involved in regulating production & storage of melanin

Structure

• belongs to the IRF family
• contains 1 tryptophan pentad repeat DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• lymphoid cells
• not induced by interferons

Pathology

• chromosomal translocation t(6;14)(p25;q32) involving IRF4 with the IgH locus may be a cause of multiple myeloma
• associated with the greying of hair

More general terms

• interferon regulatory factor family

Database

• UniProt: http://www.uniprot.org/uniprot/Q15306.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3662
• OMIM: https://mirror.omim.org/entry/254500
• OMIM: https://mirror.omim.org/entry/601900
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3662