drugs that may affect liver function tests (LFTs)
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Etiology
- drugs causing BOTH hepatocellular injury & cholestasis[1]
- acetohexamide
- allopurinol
- aminosalicylic acid
- amodiaquine
- Amphotericin B
- anabolic agents
- androgens
- chlorpropamide
- cyclophosphamide
- desipramine
- erythromycin
- glycopyrrolate
- haloperidol
- halothane
- hydrazine
- imipramine
- indomethacin
- isoniazid
- lincomycin
- MAO inhibitors
- mercaptopurine
- metaxalone
- methoxysalen
- methoxyflurane
- methyldopa
- methylthiouracil
- nicotinic acid
- nitrofurantoin
- novobiocin
- oleandomycin
- oxazepam
- oxyphenbutazone
- paraldehyde
- paramethadione
- phenacemide
- phenacetin
- phenothiazines
- phenylbutazone
- progestins
- propylthiouracil
- quinacrine (mepacrine)
- sulfonamides
- tetracyclines
- thiosemicarbazones
- thiothixene
- tolazamide
- tolbutamide
- trimethadione
- uracil mustard
- drugs causing cholestasis[2]:
- aminosalicylic acid
- amitriptyline
- anabolic steroids
- androgens
- azathioprine
- benzodiazepines
- carbamazepine
- carbarsone
- chlorthiazide
- chlorpropamide
- clavulanic acid
- dapsone
- erythromycin
- estrogens
- ethionamide
- glyburide (glibenclamide)
- gold salts
- imipramine
- mercaptopurine
- methimazole
- mitoxnatrone
- nicotinic acid
- nitrofurantoin
- oral contraceptives
- penicillamine
- penicillins
- phenothiazines
- phenylbutazone
- progestins
- propoxyphene
- sulfonamides
- sulfones
- sulindac
- tamoxifen
- tolbutamide
- drugs causing hepatocellular injury[2]:
- acetaminophen
- allopurinol
- aminosalicylic acid
- amiodarone
- amitriptyline
- androgens
- asparaginase
- aspirin
- azathioprine
- carbamazepine
- chenodiol
- chlorambucil
- chloramphenicol
- chlorpropamide
- cimetidine
- cyclosporine
- danazol
- dantrolene
- dapsone
- diclofenac
- dicoumarol (rare)
- disulfiram
- estrogens
- ethanol
- ethionamide
- etretinate
- fluconazole
- halothane
- ibuprofen
- imipramine
- indomethacin
- iron salts (overdose)
- isoniazid
- ketoconazole
- MAO inhibitors
- mercaptopurine
- methotrexate
- methoxyflurane
- methyldopa
- naproxen
- nicotinic acid
- nitrofurantoin
- oral contraceptives
- papaverine
- paramethadione
- perhexiline
- phenazopyridine
- phenindione
- phenobarbital
- phenylbutazone
- phenytoin
- plicamycin (mithramycin)
- probenecid
- procainamide
- propylthiouracil
- pyrazinamide
- quinidine
- rifampin
- salicylates
- sulfasalazine
- sulfonamides
- tamoxifen
- tetracyclines
- trimethadione
- valproic acid
- vitamin A
- warfarin (rare)
Laboratory
- increased urine bilirubin
- increased serum alkaline phosphatase (ALP)
- increased serum bilirubin
- increased serum alanine aminotransferase (ALT)
- increased serum aspartate aminotransferase (AST)
- decreased serum glucose