acetohexamide (Dymelor)

Introduction

Tradename: Dymelor.

Dosage

start with 250 mg PO QD, max 1500 mg/day divided BID

Tabs: 250 & 500 mg. Active metabolite: hydroxyhexamide.

Adverse effects

• transient leukopenia
• thrombocytopenia
• hemolytic anemia
• pancytopenia
• gastrointestinal disturbances
• headache
• tinnitus
• photosensitivity
• allergic skin reactions
• intolerance to alcohol
• hypoglycemia
• hepatic dysfunction

• drug adverse effects of sulfonylureas
• drug adverse effects of hypoglycemic agents

Drug interactions

• agents that increase risk of hypoglycemia
  • sulfonamides, beta-blockers, salicylates, clofibrate, phenylbutazone, probenecid, dicumorol, warfarin, chloramphenicol, MAO inhibitors, alcohol

• drug interaction(s) of sulfonylureas with warfarin
• drug interaction(s) of beta-adrenergic receptor antagonists with sulfonylureas
• drug interaction(s) of fluroquinolones with sulfonylureas
• drug interaction(s) of macrolides with sulfonylureas
• drug interaction(s) of salicylates with sulfonylureas
• drug interaction(s) of gliptins with sulfonylureas
• drug interaction(s) of fluoroquinolones with hypoglycemic agents

Laboratory

• specimen: serum
• methods: HPLC, GLC, color
• interferences:
  • color: hemolysis, primary & secondary amines
  • GLC: plasma lipids

Mechanism of action

• sulfonylurea
• small diuretic effect

More general terms

• sulfonylurea

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1989