pyrazinamide; PZA (Tebrazid [Canada])

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Indications

Contraindications

Dosage

  • 15-30 mg/kg up to 2000 mg PO QD
  • max dose 2-3 g/day
  • 50-70 mg/kg twice weekly has been used for compliance
  • generally given for 2 months

Tabs: 500 mg.

Dosage adjustment in renal failure

Table

creatinine clearance dosage[7]
> 50-90 mL/min 25 mg/kg every 24 hours
10-50 mL/min 25 mg/kg every 24 hours
< 10 mL/min* 12-25 mg/kg every 24 hours

* 40 mg/kg 24 hours prior to each 3 times/week hemodialysis

# no dose adjustment (with or without dialysis)[5]

Pharmacokinetics

elimination via liver

elimination via kidney

1/2life = 9-10 hours

Monitor

Adverse effects

Drug interactions

Test interactions

  • may interfere with test reading of urine ketostix

Mechanism of action

More general terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Am Thoracic Soc, Am J Respir Crit Care Med 149:1359, 1994
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. 5.0 5.1 Kaiser Permanente, Northern California, Infection Control Update, 9/2000
  6. Journal Watch 21(19):155, 2001 MMWR Morb Mort Wkly Rep 50:733, 2001
  7. 7.0 7.1 7.2 Sanford Guide to antimicrobial therapy 2001
  8. 8.0 8.1 Prescriber's Letter 10(9):49 2003
  9. 9.0 9.1 Prescriber's Letter 17(7): 2010 Recommended Lab Monitoring for Common Medications Liver Function Test Scheduling Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260704&pb=PRL (subscription needed) http://www.prescribersletter.com
  10. 10.0 10.1 10.2 10.3 Medical Knowledge Self Assessment Program (MKSAP) 16, 17. American College of Physicians, Philadelphia 2012, 2015

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