isoniazid/pyrazinamide/rifampin (Rifater)

Contraindications

pregnancy-category C

safety in lactation ?

Dosage

• 50 mg isoniazid + 120 mg rifampin + 300 mg pyrazinamide.
• Tuberculosis:
  • 6 tabs PO QD if weight > 55 kg
  • 5 tabs PO QD if weight > 45-55 kg
  • 4 tabs PO QD if weight < 45 kg

Pharmacokinetics

elimination: liver > kidney

More general terms

• anti-tuberculous combination

Components

• isoniazid; isonicotinic acid hydrazide (INH, Nydrazid, Hyzyd, Laniazid, Niazid)
• pyrazinamide; PZA (Tebrazid [Canada])
• rifampin; rifampicin (Rifadin, Rimactane)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=457276