glycopyrrolate (Robinul, Cuvposa, Qbrexza)
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Introduction
Tradenames: Robinul, Cuvposa, Qbrexza. (glycopyrronium bromide)
Indications
- used preoperatively to reduce salivary, tracheobronchial & pharyngeal secretions
- used to prevent cholinergic effects during surgery, i.e. cardiac arrhythmias, hypotension, bradycardia
- adjunct agent in management of peptic ulcer disease
- reversal of neuromuscular blockade
- drooling
- irritable bowel syndrome, diarrhea[5]
- axillary hyperhidrosis (topical)
Contraindications
- myasthenia gravis[7]
- unstable cardiovascular status
- acute hemorrhage
- glaucoma
- paralytic ileus
- severe ulcerative colitis
- Sjogren syndrome[7]
- when anticholinergic agents (parasympatholytics) are contraindicated
Dosage
- induction (intraoperative)
- control of secretions
- 4-10 ug/kg every 3-4 hours
- maximum: 0.2 mg/dose or 0.8 mg/day
- 1-2 mg PO BID/TID
Tabs: 1 & 2 mg.
Injection: 0/2 mg/mL (1 mL, 5 mL, 20 mL)
Solution: Cuvposa is a flavored oral solution for children
Topical: Qbrexza (anticholinergic cloth)
Pharmacokinetics
- following IV administration, onset of action is 1 minute
- after IM or SC administration, onset of action is 15-30 min
- inhibition of salivation persists for up to 7 hours
- does NOT reach significant levels in CSF
- excreted largely unchanged in the bile & feces
- also eliminated in the urine
elimination via kidney
Adverse effects
- common (> 10%)
- constipation
- decreased sweating
- dry mouth, nose, throat or dry skin
- urinary retention[2]
- irritation at site of injection
- less common (1-10%)
- decreased flow of breast milk
- difficulty swallowing
- photosensitivity
- uncommon (< 1%)
- rash, confusion, increased intraocular pain, orthostatic hypotension, bloating, difficult urination[3], blurred vision, drowsiness, headache, loss of memory, nausea/vomiting, weakness, tiredness, ventricular fibrillation, tachycardia, palpitations, ataxia
Mechanism of action
More general terms
Component of
- budesonide/formoterol/glycopyrrolate (Breztri Aerosphere)
- formoterol/glycopyrrolate (Bevespi Aerosphere)
- glycopyrrolate/neostigmine
References
- ↑ Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1998
- ↑ 2.0 2.1 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
- ↑ 3.0 3.1 Kaiser Permanente Northern California Regional Drug Formulary, 1998
- ↑ FDA NEWS RELEASE, July 28, 2010 FDA Approves Drug for Chronic Drooling in Children http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm220444.htm
- ↑ 5.0 5.1 Deprecated Reference
- ↑ Brooks M FDA OKs New Topical Treatment for Excessive Underarm Sweating. Medscape - Jun 29, 2018 https://www.medscape.com/viewarticle/898719
- ↑ 7.0 7.1 7.2 James W Fast Five Quiz: Hyperhidrosis Medscape. July 5, 2023 https://reference.medscape.com/viewarticle/992459