glycopyrrolate (Robinul, Cuvposa, Qbrexza)

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Introduction

Tradenames: Robinul, Cuvposa, Qbrexza. (glycopyrronium bromide)

Indications

Contraindications

pregnancy category = b

safety in lactation = -

Dosage

Tabs: 1 & 2 mg.

Injection: 0/2 mg/mL (1 mL, 5 mL, 20 mL)

Solution: Cuvposa is a flavored oral solution for children

Topical: Qbrexza (anticholinergic cloth)

Pharmacokinetics

  • following IV administration, onset of action is 1 minute
  • after IM or SC administration, onset of action is 15-30 min
  • inhibition of salivation persists for up to 7 hours
  • does NOT reach significant levels in CSF
  • excreted largely unchanged in the bile & feces
  • also eliminated in the urine

elimination via kidney

Adverse effects

Mechanism of action

More general terms

Component of

References

  1. Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1998
  2. 2.0 2.1 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. 3.0 3.1 Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. FDA NEWS RELEASE, July 28, 2010 FDA Approves Drug for Chronic Drooling in Children http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm220444.htm
  5. 5.0 5.1 Deprecated Reference
  6. Brooks M FDA OKs New Topical Treatment for Excessive Underarm Sweating. Medscape - Jun 29, 2018 https://www.medscape.com/viewarticle/898719
  7. 7.0 7.1 7.2 James W Fast Five Quiz: Hyperhidrosis Medscape. July 5, 2023 https://reference.medscape.com/viewarticle/992459

Database