phenacetin (Acetophenetidin)

Introduction

Non-narcotic analgesic removed from over the counter remedies in USA because of adverse effects:

Pharmacokinetics

• metabolized to acetaminophen

elimination via liver

1/2life = 0.6 hours

protein binding = 39 %

Adverse effects

• nephrotoxicity (including capillary necrosis)
• hemolysis
• thrombocytopenia
• methemoglobinemia

Laboratory

• specimen: plasma (EDTA)
• methods: GLC, HPLC, color, GC-MS
• interferences:
  • theophylline interferes with some HPLC procedures
  • silyl derivatives for GLC are unstable
  • colorimetric assays are non-specific

More general terms

• analgesic (antalgic)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4754