drug-nutrient interactions

Etiology

Antacids

• NaHCO3, aluminum hydroxide)
  • folate, phosphate, Ca+2, copper deficiency

Anticonvulsants

• phenytoin, phenobarbital, primidone
  • vitamin D, vitamin K & folate deficiency
• valproate -> carnitine deficiency

Antibiotics

• tetracycline -> Ca+2 deficiency
• gentamcin -> K+, Mg+2 deficiency
• neomycin -> fat malabsorption, nitrogen depletion
• trimethoprim -> folate deficiency
• isoniazid -> vitamin B6, niacin, vitamin D deficiency

Antibacterial agents

• boric acid -> riboflavin deficiency

Antimalarials

• pyrimethamine -> folate deficiency

Anti-inflammatory agents

• sulfasalazine -> folate deficiency
• colchicine -> fat malabsorption, vitamin B12 deficiency
• NSAIDs, aspirin -> iron deficiency
• glucocorticoids -> vitamin D, Ca+2 deficiency

Antineoplastic agents

• methotrexate -> folate, Ca+2 deficiency
• cisplatin -> Mg+2 deficiency

Anticoagulants

• warfarin -> vitamin K deficiency

Antihypertensive agents

• hydralazine -> vitamin B6 deficiency

Diuretics:

• thiazides -> K+ deficiency, Mg+2 deficiency
• furosemide -> K+, Ca+, Mg+2 deficiency
• triamterene -> folate deficiency

H2-receptor antagonists

• cimetidine, ranitidine, famotidine
  • vitamin B12, folate, vitamin C, zinc deficiency

Hypolipidemic agents

• cholestyramine -> fat malabsorption
• colestipol
  • vitamin K, vitamin A, folate, vitamin B12 deficiency

Laxatives:

• mineral oil -> vitamin A, vitamin D, vitamin K deficiency
• Senna -> fat malabsorption, K+, Ca+ deficiency

Proton pump inhibitors

• omeprazole
  • vitamin B12, folate, Ca+2, vitamin C, zinc deficiency

Tranquilizers

• chlorpromazine -> riboflavin deficiency

More general terms

• drug interaction

Additional terms

• disease-nutrition interactions
• nutrition