metolazone (Zaroxolyn, Diulo, Mykrox)

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Introduction

Tradenames: Zaroxolyn, Diulo, Mykrox.

Indications

Dosage

  • start 5 mg PO QD
  • max 20 mg/day
  • children: 0.2-0.4 mg/kg/day (QD or BID dosing)

Tabs: 2.5, 5, 10 mg

Pharmacokinetics

  • incompletely & poorly absorbed after oral administration
  • 50-70% of drug is bound to erythrocytes
  • 33% of drug is bound to plasma proteins
  • onset of action is 30-60 minutes
  • 70-95% of the drug is excreted in the urine unchanged
  • elimination 1/2life is 14 hours

elimination via kidney

elimination via liver

1/2life = 14 hours

elimination by hemodialysis = -

Adverse effects

Drug interactions

Mechanism of action

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
  2. Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 123
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998

Database