peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1 (PIN1)

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Function

Expression

  • expressed at low levels in most normal tissues
  • expression is increased with cell proliferation

Pathology

More general terms

Additional terms

References

  1. Wulf GM et al, Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J Biol Chem 277:47976-9, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11090625 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12388558
  2. 2.0 2.1 Zhou XZ, Kops O, Werner A, Lu PJ, Shen M, Stoller G, Kullertz G, Stark M, Fischer G, Lu KP. Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins. Mol Cell. 2000 Oct;6(4):873-83. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11090625
  3. 3.0 3.1 Liou YC et al, Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424:556-60, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12891359
  4. 4.0 4.1 Lu KP, Liou YC, Zhou XZ. Pinning down proline-directed phosphorylation signaling. Trends Cell Biol. 2002 Apr;12(4):164-72. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11978535
  5. Lu KP Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics. Cancer Cell. 2003 Sep;4(3):175-80. Review. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14522251
  6. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5300
  7. 7.0 7.1 Smet C, Sambo AV, Wieruszeski JM, Leroy A, Landrieu I, Buee L, Lippens G. The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau Biochemistry 43(7):2032-40, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14967043
  8. Bao L, Kimzey A, Sauter G, Sowadski JM, Lu KP, Wang DG. Prevalent overexpression of prolyl isomerase Pin1 in human cancers Am J Pathology 164(5):1727-37, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15111319

Database