M-phase phosphoprotein 1; MPP1; kinesin-related motor interacting with PIN1 (MPHOSPH1, KRMP1, KIF20B)
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Function
- plus-end-directed motor enzyme required for completion of cytokinesis
- interacts with PIN
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure
- belongs to the kinesin-like protein family
- contains 1 kinesin-motor domain
Compartment
- cytoplasm, nucleus
- localizes mainly in nucleus during interphase
- during prophase & metaphase, found throughout cytoplasm
- at anaphase, concentrated in the mid-body
Alternative splicing
named isoforms=5
Expression
- expressed in brain, ovary, kidney, testis
- 2-3 fold expression increase is seen as cells progress from G1 to G2/Mphase