eukaryotic initiation factor 2C1; protein argonaute-1; Argonaute1; hAgo1; argonaute RISC catalytic component 1; eukaryotic translation initiation factor 2C 1; eIF-2C 1; eIF2C 1; RNA-binding protein Q99 (AGO1, EIF2C1)

Function

• required for RNA-mediated gene silencing (RNAi)
• binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), & represses translation of mRNAs complementary to them
• lacks endonuclease activity & does not appear to cleave target mRNAs
• also required for transcriptional gene silencing of promoter regions complementary to bound short antigene RNAs
• interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 & YBX1
• associates with polysomes & messenger ribonucleoproteins (mNRPs)
• interacts with LIMD1, WTIP & AJUBA
• interacts with APOBEC3F, APOBEC3G & APOBEC3H

Structure

• belongs to the argonaute family, Ago subfamily
• contains 1 PAZ domain
• contains 1 Piwi domain

Compartment

cytoplasm, P-body

More general terms

• eukaryotic initiation factor subunit

Component of

• eukaryotic initiation factor 2C

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26523
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26523
• OMIM: https://mirror.omim.org/entry/606228
• UniProt: http://www.uniprot.org/uniprot/Q9UL18.html