endoribonuclease Dicer; helicase with Rnase motif; Helicase MOI (DICER1, DICER, HERNA, KIAA0928)

Function

• required for formation of the RNA induced silencing complex (RISC complex)
• component of the micro-RNA loading complex (miRLC)
• interacts with DHX9, EIF2C1, PIWIL1 & PRKRA
• associates with the 60S ribosome ,

Cofactor:

• binds 2 Mg+2 or Mn+2 per subunit (probable)

Structure

• belongs to the helicase family, Dicer subfamily
• contains 1 Dicer dsRNA-binding fold domain
• contains 1 DRBM (double-stranded RNA-binding) domain
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain
• contains 1 PAZ domain
• contains 2 Rnase III domains

Compartment

cytoplasm

Pathology

• defects in DICER1 are a cause of pleuropulmonary blastoma
• defects in DICER1 are the cause of multinodular goiter type 1 with or without Sertoli-Leydig cell tumors, usually of the ovary

Notes

• uncertain whether Met-1 or Met-11 is the initiator

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)
• endoribonuclease
• phosphoprotein

Additional terms

• telomere

Component of

• RNA-induced silencing complex (RISC)
• RISC loading complex; micro-RNA loading complex (miRLC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23405
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23405
• OMIM: https://mirror.omim.org/entry/138800
• OMIM: https://mirror.omim.org/entry/601200
• OMIM: https://mirror.omim.org/entry/606241
• UniProt: http://www.uniprot.org/uniprot/Q9UPY3.html