RISC loading complex; micro-RNA loading complex (miRLC)

Function

• within the miRLC, DICER1 & TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs & then load them onto EIF2C2/AGO2
• EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC complex & may subsequently dissociate from DICER1 & TARBP2
• also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs

Structure

• subunits include: DICER1, EIF2C2/AGO2 & TARBP2

More general terms

• molecular complex

Additional terms

• RNA-induced silencing complex (RISC)