RNA-binding protein 4 (RNA-binding motif protein 4, RNA-binding motif protein 4a, Lark homolog, hLark, RBM4, RBM4A)

Function

• role in alternative splice site selection during pre-mRNA processing (putative)
• binds TNPO3, which mediates nuclear import of the protein
  • disrupted by nuclear Ran bound to GTP

Structure

• contains 1 CCHC-type zinc finger
• contains 2 RRM domains (RNA recognition motif domains)

Compartment

• nucleus, nucleolus, cytoplasm
• may undergo nuclear-cytoplasmic shuttling

Alternative splicing

named isoforms=3

Expression

• ubiquitously expressed
• expressed in fetal brain

Pathology

• down-regulated in fetal Down syndrome brain

More general terms

• RNA-binding protein
• zinc finger protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/602571
• UniProt: http://www.uniprot.org/uniprot/Q9BWF3.html