Wilms tumor protein 1-interacting protein (WT1-interacting protein, WTIP)
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Function
- may monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes
- in case of podocyte injury, shuttles into the nucleus & acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression & a less differentiated phenotype (putative)
- interacts with CD2AP & WT1 (putative)
Structure
- belongs to the zyxin/ajuba family
- contains 3 LIM Zn+2-binding domains
Compartment
- cell junction, adherens junction
- nucleus (putative)
- translocates from cell-cell junctions to the nucleus in puromycin aminonucleoside-treated podocytes (putative)