DEAD box protein 5; ATP-dependent RNA helicase DDX5; RNA helicase p68 (DDX5, G17P1, HELR, HLR1)

Function

• RNA-dependent ATPase activity
• ATP hydrolysis isstimulated by single-stranded RNA
• may be involved in pre-mRNA splicing
• identified in the spliceosome C complex

Structure

• Arg-502 is dimethylated, probably to asymmetric dimethylarginine
• belongs to the DEAD box helicase family, DDX5/DBP2 subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

nucleus, nucleolus

More general terms

• DEAD box ATP-dependent helicase
• phosphoprotein

Component of

• spliceosome C complex

Database

• UniProt: http://www.uniprot.org/uniprot/P17844.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1655
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1655
• OMIM: https://mirror.omim.org/entry/180630