ATP-dependent RNA helicase DHX36 (DEAH box protein 36, MLE-like protein 1, RNA helicase associated with AU-rich element ARE, DHX36, DDX36, KIAA1488, MLEL1, RHAU)

Function

• role in degradation & deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element
• role in sex development & spermatogenesis (putative)
• interacts with PARN, EXOSC3 & EXOSC10

Structure

• belongs to the DEAD box helicase family, DEAH subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

• nucleus, cytoplasm
• isoform 1 preferentially localized to nucleus
• isoform 2 localized to cytoplasm
• partitioning of cellular localization between nucleus & cytoplasm is not exclusive, as isoform 1 also detected in cytoplasm.
• both isoforms excluded from nucleoli

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H2U1.html