Abl interactor 1; Abelson interactor 1; Abi-1; Abl-binding protein 4; AblBP4; eps8 SH3 domain-binding protein; eps8-binding protein; Nap1-binding protein; Nap1BP; spectrin SH3 domain-binding protein 1; e3B1 (ABI1, SSH3BP1)

^[1]^[2]

Function

negative regulation of cell growth & transformation
interacts with nonreceptor tyrosine kinases ABL1 &/or ABL2
regulation of EGF-induced Erk pathway activation
cytoskeletal reorganization & EGFR signaling
transduction of signals from Ras to Rac in association with EPS8
- trimeric complex of ABI1, EPS8, SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity
- ABI1 acts as an adapter in the complex
regulates ABL1-mediated phosphorylation of MENA
recruits WASF1 to lamellipodia
regulates WASF1 protein level
interacts with ABL1, MENA, STX1A, SNAP25, VAMP2, EPS8, WASF1, SOS1, SOS2, GRB2, SPTA1, NCKAP1, NCK1 (+/-)
in vitro substrate for v-Abl
phosphorylated on Tyr after induction by v-Abl
component of complex consisting of ABI1, STX1A, SNAP25
component complex consisting of ABI1, EPS8, SOS1
component of the WAVE2 complex

the t-SNARE coiled-coil homology domain is necessary & sufficient for interaction with STX1A (putative)
belongs to the ABI family
contains 1 SH3 domain
contains 1 t-SNARE coiled-coil homology domain

named isoforms=11

chromosomal translocation t(10;11)(p11.2;q23) involving ABI1 & MLL associated with acute leukemia